Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune complexes in psoriasis with and without arthritis.

J Karsh, L R Espinoza, G Dorval

    The Journal of Rheumatology
    |January 1, 1978
    PubMed
    Summary

    Soluble immune complexes were investigated in psoriasis patients. The Clq deviation method detected these complexes in 29% of psoriasis patients and 35% with psoriatic arthritis, unlike the Raji cell assay.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Antiglomerular basement disease in children: Literature review and therapeutic options].

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2017
    Same author

    Spatial optical beam steerin with an AlGaAs integrated phased array.

    Applied optics·2010
    Same author

    Characterization of an AlGaAs rib waveguide using a grating in a Fabry-Perot étalon configuration.

    Applied optics·2010
    Same author

    Specificity of antinuclear factor testing: what does specific mean?

    Canadian Medical Association journal·2010
    Same author

    Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial.

    Arthritis and rheumatism·2010
    Same author

    CHEMICAL CHARACTERIZATION OF GLYCOPEPTIDES FROM HUMAN gammaM-GLOBULINS.

    The Journal of experimental medicine·2009

    Area of Science:

    • Immunology
    • Dermatology
    • Rheumatology

    Background:

    • Soluble immune complexes (SICs) are implicated in various autoimmune and inflammatory conditions.
    • Psoriasis and psoriatic arthritis are chronic inflammatory diseases with complex pathogenesis.
    • The role of SICs in psoriasis and psoriatic arthritis requires further elucidation.

    Purpose of the Study:

    • To investigate the presence and prevalence of soluble immune complexes in patients with psoriasis and psoriatic arthritis.
    • To compare the efficacy of two different assays in detecting SICs in these patient cohorts.

    Main Methods:

    • Serum samples from a large cohort of patients with psoriasis and psoriatic arthritis were analyzed.
    • Two distinct assays were utilized: the Raji cell assay and the Clq deviation assay.

    Related Experiment Videos

  • Detection of Clq-reacting material was assessed as an indicator of SICs.

    • Main Results:

    • The Raji cell assay did not detect any evidence of soluble immune complexes in the patient sera.
    • The Clq deviation method identified Clq-reacting material in 29% of patients with psoriasis alone.
    • Sera from 35% of patients with associated psoriatic arthritis also exhibited Clq-reacting material.

    Conclusions:

    • The Clq deviation method appears to be more sensitive for detecting soluble immune complexes in psoriasis and psoriatic arthritis compared to the Raji cell assay.
    • The presence of Clq-reacting material in a significant proportion of patients suggests a potential role for immune complexes in the pathophysiology of these diseases.