Association Between Acute Myocardial Infarction and Cognition
Michelle C Johansen1, Wen Ye2, Alden Gross1
1The Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA Neurology
|May 30, 2023
Summary
Myocardial infarction (MI) does not immediately impact cognition but is linked to accelerated cognitive decline over time. Preventing MI may be crucial for maintaining long-term brain health.
Area of Science:
- Cardiology
- Neuroscience
- Public Health
Background:
- The impact of myocardial infarction (MI) on cognitive function remains unclear.
- Assessing cognitive changes post-MI is crucial for understanding long-term health outcomes.
Purpose of the Study:
- To determine if incident MI is associated with changes in cognitive function.
- To adjust for pre-MI cognitive trajectories in the analysis.
Main Methods:
- Pooled data from 6 US population-based cohort studies (1971-2019).
- Included 30,465 adults without prior MI, dementia, or stroke.
- Linear mixed-effects models analyzed changes in global cognition, memory, and executive function.
Main Results:
- Incident MI was not associated with acute cognitive decline.
- Individuals with MI showed faster long-term declines in global cognition, memory, and executive function.
- Race and sex influenced the rate of cognitive decline post-MI.
Conclusions:
- Incident MI is not linked to immediate cognitive impairment but accelerates cognitive decline over time.
- Prevention of MI is vital for preserving long-term brain health.
- Findings highlight the importance of cardiovascular health for cognitive well-being.
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