Related Experiment Video

Updated: Sep 7, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

The special affinity of particular types of Proteus mirabilis for the urinary tract

B W Senior

    Journal of Medical Microbiology
    |February 1, 1979
    PubMed

    Insights

    Proteus mirabilis strains causing urinary-tract infections, particularly in the elderly, were identified. Specific P/S types showed a higher prevalence in patients, suggesting a urinary tract affinity.

    Area of Science:

    • Microbiology
    • Infectious Diseases

    Background:

    • Proteus species are common causes of urinary-tract infections (UTIs).
    • Understanding Proteus strain characteristics is crucial for managing UTIs, especially in vulnerable populations.

    Purpose of the Study:

    • To isolate, identify, and characterize Proteus species from urine samples.
    • To determine the P/S (proticine production/sensitivity) types of isolated strains.
    • To investigate the association between specific Proteus P/S types and UTIs.

    Main Methods:

    • Isolation and identification of Proteus species from 217 urine samples.
    • Typing of strains for proticine production (P type) and sensitivity (S type).
    • Analysis of P/S types frequency and correlation with clinical UTI symptoms.

    Main Results:

    • Proteus strains, predominantly P. mirabilis, were frequently isolated from elderly patients with UTIs.
    • Ninety-seven distinct P/S types were identified.
    • Three specific P/S types (P3/S1,8, P3/S1,8,13, and P3/S1,13) occurred at a significantly higher frequency (14%) than expected from fecal carriage rates.

    Conclusions:

    • Certain Proteus P/S types exhibit a higher prevalence in patients with symptomatic UTIs.
    • These specific P/S types may possess a particular affinity for the urinary tract, warranting further investigation.

    More Related Videos

    Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice08:53

    Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

    Published on: December 4, 2020

    An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection07:57

    An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

    Published on: June 24, 2025

    Related Concept Videos

    Drug Elimination by Renal Route: Tubular Secretion01:15

    Drug Elimination by Renal Route: Tubular Secretion

    Once the process of glomerular filtration is completed, blood carrying unfiltered drug molecules traverses through efferent arterioles and makes its way into the peritubular capillaries in the proximal tubule. A variety of carriers play a pivotal role in actively secreting drugs from these peritubular capillaries into the tubular fluid. The organic anion transporter transfers acidic drugs, against an electrochemical gradient, from the peritubular capillaries into the renal tubule cells and...
    Urinary Tract Infection I: Introduction01:26

    Urinary Tract Infection I: Introduction

    Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
    Urinary Tract Infection II: Pathophysiology01:25

    Urinary Tract Infection II: Pathophysiology

    The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

    A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
    Urine Studies II: Urine Culture and Sensitivity Test01:26

    Urine Studies II: Urine Culture and Sensitivity Test

    A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
    Microbiota of the Urogenital Tract01:28

    Microbiota of the Urogenital Tract

    The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...