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The Histopathology of Cold Agglutinin Disease-Associated B-Cell Lymphoproliferative Disease
Angela Guenther1, Anne Tierens1, Agnieszka Malecka2
1Laboratory Medicine Program, University Health Network and University of Toronto, Toronto, Canada.
Objectives:
Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen, a carbohydrate expressed on most cells, including red blood cells. The underlying disease has been characterized in recent years as a distinct B-cell lymphoproliferative disease of the bone marrow, occurring mostly in the elderly. The disease has been now been included as a separate entity in the most recent classifications of mature B-cell neoplasms.
Methods:
A review of the characteristics of cold agglutinin disease is provided, with an emphasis on the pathology features.
Results:
A detailed description of the histopathology, immunophenotype, and genetics of cold agglutinin disease is provided and compared to other B-cell lymphoproliferative diseases in the bone marrow with similar features.
Conclusions:
Recognition of the pathology features of cold agglutinin disease allows to distinguish it from other diseases, especially lymphoplasmacytic lymphoma and marginal zone lymphoma.
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