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Monitoring methotrexate toxicity: Are we being over-vigilant?

Prabha Ranganathan1

  • 1Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

BMJ (Clinical Research Ed.)
|May 30, 2023
PubMed
Abstract

No abstract available in PubMed .

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
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