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Characteristics of posterior zone I retinopathy of prematurity

Tapas R Padhi1,2, Miloni Shah3, Suman Sahoo3

  • 1Anant Bajaj Retina Institute, L V Prasad Eye Institute (Mithu Tulsi Chanrai Campus), Bhubaneswar, India. tapas@lvpei.org.

Eye (London, England)
|May 30, 2023
PubMed

Insights

Retinopathy of prematurity (ROP) in posterior Zone I is linked to unblended oxygen and poor weight gain. This condition presents unique clinical features distinct from ROP in other zones.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Perinatal Medicine

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
  • Posterior Zone I ROP, while less common, can have severe visual consequences.
  • Understanding the specific characteristics of ROP in this zone is crucial for timely intervention.

Purpose of the Study:

  • To detail the demographic and clinical features of ROP in posterior Zone I.
  • To identify risk factors and unique presentations of ROP in this specific retinal zone.
  • To differentiate posterior Zone I ROP from ROP in other zones.

Main Methods:

  • A combined retrospective (10 years) and prospective (1 year) study.
  • Analysis of 130 eyes from 67 infants with posterior Zone I ROP.
  • Data collection included gestational age, birth weight, oxygen use, and weight gain patterns.

Main Results:

  • Mean gestational age: 29.3 weeks; mean birth weight: 1217.3 grams.
  • 91.1% of infants had poor weekly weight gain (<100g).
  • Aggressive ROP subtypes were most common (60%); atypical features like bleb-like detachment and preretinal deposits were observed.

Conclusions:

  • Posterior Zone I ROP in this cohort was associated with 100% unblended oxygen, poor weight gain, and systemic co-morbidities.
  • ROP in posterior Zone I exhibits a distinct profile with atypical characteristics.
  • These findings highlight the need for targeted monitoring and management strategies for posterior Zone I ROP.
Abstract

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