Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery
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A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture
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Taichi Tsuneishi1, Keiichi Kojima1,2, Fumika Kubota3
1Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8530, Japan. sudo@okayama-u.ac.jp.
Chemical Communications (Cambridge, England)
|May 31, 2023
Abstract:
Light-driven inward proton pump rhodopsin RmXeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a photoswitchable carrier utilized for intracellular substance delivery.
