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Updated: Jul 28, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

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Association between sleep pattern and pharmacological treatment in children with attention deficit disorder with

Nathalia Sena Rocha1, Rogério do Espírito Santo Amorim Correa1, Adria Carolina de Melo Dias1

  • 1Universidade do Estado do Pará, Marabá, PA, Brasil.

Revista Paulista De Pediatria : Orgao Oficial Da Sociedade De Pediatria De Sao Paulo
|May 31, 2023
PubMed

Insights

Pharmacological treatments for attention deficit hyperactivity disorder (ADHD) can improve symptoms but may negatively impact children's sleep. Atomoxetine appears to have fewer sleep-related side effects compared to other ADHD medications.

Area of Science:

  • Pediatric Neurology
  • Sleep Medicine
  • Pharmacology

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Sleep disturbances are frequently observed in children with ADHD, impacting their daily functioning and treatment outcomes.

Approach:

  • A comprehensive literature search was conducted across major scientific databases (Cochrane Library, PubMed, LILACS, Embase, Scopus, CINAHL, Web of Science).
  • The search focused on studies evaluating the effects of various pharmacological treatments on the sleep patterns of children diagnosed with ADHD.

Key Points:

  • Several ADHD medications, including guanfacine, methylphenidate, dasotraline, L-theanine, and lisdexamfetamine, were found to reduce ADHD symptoms.
  • However, all these medications, with the exception of atomoxetine, were associated with adverse effects on sleep quality.
  • Observed sleep disturbances included reduced rapid eye movement (REM) and non-REM sleep, decreased slow-wave sleep, and prolonged sleep onset latency.

Conclusions:

  • Pharmacological interventions for ADHD can negatively affect sleep quality in pediatric populations.
  • Atomoxetine demonstrated a comparatively lower impact on sleep variables among the studied ADHD medications.
Abstract

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