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Hepatitis C virus genotype diversity in Ningxia Hui autonomous region, Northwestern China

C An1, W Ma1, R F He1

  • 1People's Hospital of Ningxia Hui Autonomous Region, Department of Laboratory Medicine, Yinchuan, Ningxia, China.

Brazilian Journal of Biology = Revista Brasleira De Biologia
|May 31, 2023
PubMed

Insights

Hepatitis C virus (HCV) genotype 1b is the most common in Ningxia, China. This study analyzed 153 patients, finding GT1b, GT2a, and GT3a as the predominant HCV genotypes in the region.

Area of Science:

  • Virology
  • Hepatology
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) exhibits significant regional variations in genotype distribution.
  • Understanding these distributions is crucial for effective treatment and public health strategies.

Purpose of the Study:

  • To determine the prevalence and distribution of Hepatitis C virus genotypes among infected patients in the Ningxia Hui Autonomous Region.
  • To identify demographic patterns associated with specific HCV genotypes.

Main Methods:

  • Serum samples from 153 HCV-infected patients were analyzed.
  • Nucleic acid extraction and amplification were performed using test kits.
  • HCV viral load was quantified using reverse transcriptase PCR (RT-PCR), and genotypes were identified.

Main Results:

  • Hepatitis C virus genotype 1b was predominant (36.60%), followed by GT2a (29.40%) and GT3a (15.00%).
  • Males were more prevalent in GT1b (39.30%), while females were more prevalent in GT2a (46.30%).
  • The 41-50 year age group showed the highest HCV prevalence (32.00%).

Conclusions:

  • Hepatitis C virus genotype 1b is the most prevalent genotype in the Ningxia Hui Autonomous Region.
  • The findings highlight the specific epidemiological landscape of HCV in this region, informing targeted interventions.

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