Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Indicators

Indicators

Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Photoprintable Photothermal Actuators for Spatially Programmable Shape Morphing.

ACS nano·2026

Same author

Multifunctional Ferroelectric Bioelectronic Interfaces for Long-Term Biosafe Vagus Nerve Modulation.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Templating Methods for Materials Fabrication Across Scales.

Chemical reviews·2025

Same author

Transient Emulsions: A New Paradigm for Dynamic Colloidal Assembly.

Accounts of chemical research·2025

Same author

Natural polymer-based soft actuators: from biomass to bioapplications.

Journal of materials chemistry. B·2025

Same author

Controllable Doping for Tunable and Multimodal Emission in ZnS-Based Mechanoluminescent Nanocrystals.

Nano letters·2025

Same journal

Vertically Stacked Indium Gallium Zinc Oxide-Based Three-Dimensional Integrated Circuits.

ACS nano·2026

Same journal

Tunable Nanoparticle Thin-Film Reveals Distance Dependence of Auger-Mediated Radiation Enhancement in Diffuse Midline Glioma.

ACS nano·2026

Same journal

G-Quadruplex Network Engineering in Ionogels: Realizing Robust Biosensing Interfaces for Plant Electrophysiology.

ACS nano·2026

Same journal

Announcing the 2026 <i>ACS Nano</i> Lectureship and <i>ACS Nano</i> Impact Award Laureates.

ACS nano·2026

Same journal

Ultrafast Self-Assembly of Zeolitic Imidazolate Framework-8 Enables Antibody Orientation for Ultrasensitive Lateral Flow Immunoassays.

ACS nano·2026

Same journal

Interfacial Salt Engineering with Alkali and Ammonium Additives for Stable Pure-Blue Perovskite Light-Emitting Diodes and Micropatterned Displays.

ACS nano·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 28, 2025

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Published on: May 29, 2018

Self-Destructive Structural Color Liquids for Time-Temperature Indicating.

Chao Huang¹, Yuanyuan Shang^1,2, Jiachuan Hua¹

¹Institute of Biomedical & Health Engineering, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, P. R. China.

|May 31, 2023

Summary

This summary is machine-generated.

New self-destructive structural color liquids (SCLs) offer reliable cold chain transport monitoring for vaccines. These advanced time-temperature indicators (TTIs) provide visual cues for temperature excursions, enhancing vaccine safety.

Keywords:

photonic crystal self-destruction structural color thermal responsive time−temperature indicator

More Related Videos

A Simple Dewar/Cryostat for Thermally Equilibrating Samples at Known Temperatures for Accurate Cryogenic Luminescence Measurements

A Simple Dewar/Cryostat for Thermally Equilibrating Samples at Known Temperatures for Accurate Cryogenic Luminescence Measurements

Published on: July 19, 2016

Blue-hazard-free Candlelight OLED

Blue-hazard-free Candlelight OLED

Published on: March 19, 2017

Related Experiment Videos

Last Updated: Jul 28, 2025

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Novel Techniques for Observing Structural Dynamics of Photoresponsive Liquid Crystals

Published on: May 29, 2018

A Simple Dewar/Cryostat for Thermally Equilibrating Samples at Known Temperatures for Accurate Cryogenic Luminescence Measurements

A Simple Dewar/Cryostat for Thermally Equilibrating Samples at Known Temperatures for Accurate Cryogenic Luminescence Measurements

Published on: July 19, 2016

Blue-hazard-free Candlelight OLED

Blue-hazard-free Candlelight OLED

Published on: March 19, 2017

Area of Science:

Materials Science
Chemical Engineering
Nanotechnology

Background:

Vaccines are critical for pandemics, but cold chain transport faces challenges with current time-temperature indicators (TTIs).
Existing TTIs have limitations including instability, narrow temperature ranges, and susceptibility to environmental factors like light.
Reliable monitoring is essential to maintain vaccine efficacy throughout the supply chain.

Purpose of the Study:

To develop novel self-destructive structural color liquids (SCLs) for advanced time-temperature indication.
To overcome the limitations of conventional TTIs in cold chain monitoring.
To create a more robust and versatile solution for tracking vaccine storage conditions.

Main Methods:

Development of structural color materials utilizing fluidic properties and colloidal photonic crystals.
Engineering SCLs for triggered, irreversible color destruction via agent diffusion.
Characterization of SCLs for sensitivity, tunable destruction times, and wide temperature range compatibility.

Main Results:

Demonstrated SCLs with inherent irreversibility and superior sensitivity to temperature changes.
Achieved tunable self-destructive times ranging from minutes to days.
Validated a wide tracking temperature range from -70 to +37 °C for SCLs.
Showcased convenient packaging of SCLs into flexible TTIs for visual or mobile phone inspection.

Conclusions:

Self-destructive SCLs offer a promising next-generation solution for intelligent time-temperature indication.
These SCLs enhance compatibility with cold chain transport requirements for diverse vaccines.
The developed technology addresses shortcomings of conventional TTIs, improving vaccine safety and monitoring capabilities.