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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Myasthenia Gravis: Diagnostic Tests01:15

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Chemical Synapses01:26

Chemical Synapses

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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
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Related Experiment Video

Updated: Jul 28, 2025

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models
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Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models

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Neuromuscular Disorders Associated With COVID-19.

Larry Morgan1, Mary Hollist2, Katherine Au3

  • 1Bronson Neuroscience Center, Kalamazoo, MI, USA.

Neuroscience Insights
|May 31, 2023
PubMed
Summary
This summary is machine-generated.

The coronavirus disease 2019 (COVID-19) pandemic impacts neuromuscular disorders, causing diverse pathologies beyond respiratory issues. This review explores COVID-19

Keywords:
COVID-19myasthenia gravisneuromuscularneuropathypalsy

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The COVID-19 pandemic has significantly affected individuals with pre-existing neuromuscular disorders.
  • SARS-CoV-2 infection presents a wide spectrum of neuromuscular complications, extending beyond respiratory symptoms.
  • Understanding these neurological sequelae is crucial for patient management and prognosis.

Purpose of the Study:

  • To review the multifaceted relationship between COVID-19 infection and the neuromuscular system.
  • To catalog and discuss various neuromuscular complications associated with SARS-CoV-2.
  • To highlight the impact of COVID-19 on patients with pre-existing neuromuscular conditions.

Main Methods:

  • Literature review synthesizing current knowledge on COVID-19 and neuromuscular disorders.
  • Analysis of documented cases and clinical observations.
  • Discussion of pathological mechanisms linking SARS-CoV-2 to neuromuscular system dysfunction.

Main Results:

  • COVID-19 is associated with direct and indirect neuromuscular complications.
  • Reported conditions include critical illness neuromyopathy, peripheral nerve palsies, myalgias, and positional compressive neuropathies.
  • Exacerbation of pre-existing conditions like myasthenia gravis and Guillain-Barré syndrome are observed.

Conclusions:

  • COVID-19 poses significant risks to the neuromuscular system in both infected individuals and those with prior neuromuscular disorders.
  • Comprehensive understanding and recognition of these diverse neurological manifestations are essential.
  • Further research is needed to elucidate long-term neuromuscular outcomes and optimize treatment strategies.