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Inactive matrix Gla protein in relation to diabetic retinopathy in type 2 diabetes

Hend Adel1, Olfat Fawzy1, Eman Mahmoud1

  • 1Department of Endocrinology and Metabolism, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Journal of Diabetes and Metabolic Disorders
|May 31, 2023
PubMed
Abstract

Insights

Inactive Matrix Gla protein (MGP) is elevated in type 2 diabetes and linked to diabetic retinopathy (DR). This protein may play a role in DR development and progression.

Area of Science:

  • Endocrinology
  • Ophthalmology
  • Vascular Biology

Background:

  • Inactive Matrix Gla protein (MGP) is implicated in vascular calcification in type 2 diabetes mellitus (T2DM).
  • The role of inactive MGP in diabetic microvascular complications, specifically diabetic retinopathy (DR), is not well understood.

Purpose of the Study:

  • To investigate the association between inactive MGP and DR in patients with T2DM.
  • To explore the relationship between inactive MGP and insulin resistance.

Main Methods:

  • Study included 90 participants: 65 with T2DM (25 without DR, 40 with DR) and 25 healthy controls.
  • Serum inactive MGP levels were quantified using ELISA.
  • Insulin resistance was assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Main Results:

  • Inactive MGP levels were significantly higher in diabetic patients (with and without DR) compared to controls.
  • Patients with DR exhibited higher inactive MGP levels than those without DR.
  • Inactive MGP showed positive correlations with HbA1c, HOMA-IR, LDL-C, and triglycerides, and negative correlations with HDL-C and eGFR.
  • Logistic regression identified inactive MGP as a key factor associated with DR.

Conclusions:

  • Inactive MGP is associated with DR and insulin resistance in T2DM patients.
  • Findings suggest inactive MGP may contribute to the pathogenesis and progression of DR.
Keywords:
Diabetic retinopathyInactive matrix GlaInsulin resistanceMGPType 2 diabetes

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