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A Case of Daptomycin-Induced Rhabdomyolysis: A Life and Limb Threatening Complication

Jenna Gunn1, Kelsee K Zajac1, Katherine Esser1

  • 1Orthopaedic Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, USA.

Cureus
|May 31, 2023
PubMed

Insights

Surgical site infections are rising. A daptomycin antibiotic case study highlights rhabdomyolysis and acute compartment syndrome risks, emphasizing prompt monitoring and patient education for limb-saving interventions.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Surgical Complications

Background:

  • Surgical site infections (SSIs) are a significant cause of patient morbidity and increased healthcare costs.
  • Factors contributing to SSIs include an aging population, increased use of surgical implants, antibiotic-resistant bacteria, and patient comorbidities.
  • Daptomycin, an antibiotic, is associated with rhabdomyolysis, a severe condition that can lead to acute compartment syndrome (ACS).

Observation:

  • This case report details a patient with a penile implant infection treated with daptomycin.
  • The patient developed rhabdomyolysis and subsequent bilateral forearm acute compartment syndrome (ACS).

Findings:

  • The patient underwent emergency fasciotomies to treat ACS.
  • Long-term functional preservation of the upper extremities was achieved post-intervention.

Implications:

  • Physicians must closely monitor patients receiving intravenous daptomycin and educate them on recognizing critical symptoms.
  • Early recognition and intervention are crucial for limb and life-saving treatment in cases of daptomycin-induced rhabdomyolysis and ACS.
  • Orthopedic surgeons should maintain a high index of suspicion for ACS, particularly when rhabdomyolysis is present.
Keywords:
acute compartment syndromeadverse drug effectdaptomycin related adverse effectemergent fasciotomyrhabdomyolysis

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