Metastatic Pancreatic Acinar Cell Carcinoma: An Unlikely Culprit

Area of Science:

• Oncology
• Dermatology
• Pathology

Background:

• Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic neoplasm.
• Acinar cells, though abundant in the pancreas, infrequently undergo malignant transformation.
• PACC typically exhibits rapid hematogenous metastasis to organs like the brain, liver, lungs, and skeleton.

Observation:

• Cutaneous involvement is an uncommon manifestation of pancreatic neoplasms.
• The umbilicus is the most frequently reported site for skin metastasis.
• Other reported cutaneous sites include the trunk, lower extremities, head, and neck.

Findings:

• This report details a rare case of metastatic pancreatic acinar cell carcinoma.
• The patient presented with cutaneous involvement of the scalp.
• This represents an unusual site for PACC metastasis.

Implications:

• This case expands the understanding of PACC metastatic patterns.
• It underscores the importance of considering PACC in patients with unexplained cutaneous lesions, even in unusual locations.
• Further research may elucidate the mechanisms behind PACC's diverse metastatic potential.