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"Bone-SASP" in Skeletal Aging.
Ching-Lien Fang1, Bin Liu1, Mei Wan2,3
1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Calcified Tissue International
|May 31, 2023
Summary
Cellular senescence, marked by cell cycle arrest and the senescence-associated secretory phenotype (SASP), drives bone pathologies. Bone-SASP contributes to aging, premature aging syndromes, and osteoarthritis.
Area of Science:
- Cellular biology
- Gerontology
- Skeletal biology
Background:
- Cellular senescence is a state of stable cell cycle arrest.
- The senescence-associated secretory phenotype (SASP) involves the release of various factors.
- Senescent cells and their SASP contribute to age-associated disorders.
Purpose of the Study:
- To review the role of cellular senescence and SASP in bone pathologies.
- To focus on the impact of bone-SASP in aging and related conditions.
- To discuss the contribution of bone-SASP to osteoarthritis.
Main Methods:
- Literature review of cellular senescence and SASP.
- Focus on bone cell-associated SASP (bone-SASP).
- Analysis of bone-SASP's role in aging, premature aging syndromes, glucocorticoid-induced bone damage, and osteoarthritis.
Main Results:
- Senescent cells in bone produce SASP factors that alter skeletal structure via paracrine effects.
- Bone-SASP is implicated in natural and premature aging bone pathologies.
- Bone-SASP contributes to glucocorticoid-induced bone damage and osteoarthritis development.
Conclusions:
- Cellular senescence and bone-SASP are key mediators of bone pathologies.
- Bone-SASP plays a significant role in skeletal aging and disease.
- Understanding bone-SASP mechanisms is crucial for treating bone disorders.
Keywords:
Bone-SASPCellular senescenceOsteoarthritisOsteoporosisPremature aging syndromesProgeria syndromeSenescence-associated secretory phenotype (SASP)Skeletal agingMore Related Videos
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