Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EpiATLAS - a reference for human epigenomic research.

bioRxiv : the preprint server for biology·2026
Same author

Generation of ciBMECs: Endothelial Cells Acquire Blood-Brain Barrier Identity and Function Through Wnt Activation.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells.

Nature communications·2026
Same author

Revisiting the blueprint for an interpretable virtual cell.

Nature reviews. Genetics·2026
Same author

Mouse lemur cell atlas informs primate genes, physiology and disease.

Nature·2025
Same author

A molecular cell atlas of mouse lemur, an emerging model primate.

Nature·2025

Related Experiment Video

Updated: Jul 28, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.7K

Vascularized human brain organoid on-chip.

Sin Yen Tan1, Xiaohan Feng1, Lily Kwan Wai Cheng2

  • 1Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong. angelawu@ust.hk.

Lab on a Chip
|May 31, 2023
PubMed
Summary
This summary is machine-generated.

Brain organoids offer a window into human brain development but lack vasculature. Microfluidics can enhance these models by enabling perfusion and a blood-brain barrier, improving their utility for research.

More Related Videos

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo
04:08

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo

Published on: February 16, 2024

1.6K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

1.9K

Related Experiment Videos

Last Updated: Jul 28, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.7K
Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo
04:08

Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo

Published on: February 16, 2024

1.6K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

1.9K

Area of Science:

  • Neuroscience
  • Bioengineering
  • Developmental Biology

Background:

  • Human brain modeling in vitro is complex due to intricate cellular and structural features.
  • Brain organoids mimic human brain development but lack functional vasculature.
  • Microfluidics offers potential solutions for vascularizing brain organoids.

Purpose of the Study:

  • To review the state-of-the-art in vitro human brain models.
  • To explore microfluidic strategies for enhancing brain organoids with vasculature.
  • To discuss challenges and future directions in vascularized brain organoid development.

Main Methods:

  • Review of existing literature on brain organoids and microfluidic systems.
  • Analysis of strategies for integrating microfluidics into brain organoid culture.
  • Discussion of in vivo human brain development for comparative context.

Main Results:

  • Current brain organoids lack essential vascular perfusion.
  • Microfluidic devices can introduce vascularization and control the blood-brain barrier microenvironment.
  • Integration of microfluidics presents a promising avenue for advanced brain organoid models.

Conclusions:

  • Vascularized brain organoids are crucial for accurate physiological and pathological modeling.
  • Microfluidics is a key technology for overcoming current limitations in brain organoid development.
  • Further research is needed to address obstacles and optimize microfluidic-based vascularized brain organoids.