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The role of WD40 repeat-containing proteins in endocrine (dys)function
Yalan Hu1, Eveline Bruinstroop2, Anthony N Hollenberg3
1Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Journal of Molecular Endocrinology
|May 31, 2023
Summary
WD40 proteins are crucial for cell functions and interact with nuclear receptors. This review explores their structure, role in nuclear receptor signaling, and links to endocrine diseases like Triple-A syndrome.
Area of Science:
- Molecular Biology
- Endocrinology
- Structural Biology
Background:
- WD40 repeat-containing proteins are vital for cellular processes like signal transduction and apoptosis.
- These proteins feature a conserved WD40 domain, typically a β-propeller structure, facilitating protein-protein interactions.
- They are implicated in nuclear hormone receptor signaling, acting as coregulators in gene transcription.
Purpose of the Study:
- To review the structure of WD40 repeat-containing proteins.
- To elucidate the role of WD40 proteins in nuclear receptor signaling (corepressor/coactivator functions).
- To highlight WD40 proteins associated with endocrine pathologies.
Main Methods:
- Literature review focusing on structural and functional aspects of WD40 proteins.
- Analysis of their involvement in nuclear receptor complexes.
- Examination of clinical data linking WD40 proteins to endocrine disorders.
Main Results:
- WD40 domains serve as scaffolds for protein interactions, crucial for nuclear receptor function.
- These proteins modulate gene transcription through corepressor or coactivator activities.
- Specific WD40 proteins are linked to endocrine diseases, including congenital disorders.
Conclusions:
- WD40 proteins are integral to nuclear receptor-mediated gene regulation.
- Dysregulation of WD40 proteins contributes to various endocrine pathologies.
- Understanding these proteins offers insights into endocrine system function and disease.
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