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Related Experiment Videos

Multiple hamartomas associated with intracranial malformation.

F Mimouni, B K Han, L Barnes

    Pediatric Dermatology
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    This study reports a newborn with multiple hamartomas and brain malformation. Early brain imaging is recommended for infants with extensive epidermal nevus syndrome or giant pigmented nevi.

    Area of Science:

    • Dermatology
    • Neurology
    • Pediatrics

    Background:

    • Congenital skin anomalies, such as epidermal nevus syndrome and giant pigmented congenital nevocellular nevus, can be associated with underlying developmental abnormalities.
    • Multisystem involvement requires comprehensive diagnostic approaches.

    Observation:

    • A newborn presented with multiple hamartomas, including epidermal nevus syndrome and a giant pigmented congenital nevocellular nevus.
    • Associated anomalies included nevus flammeus, vascular malformation, cutis aplasia congenita of the scalp, cartilage hamartoma, and conjunctival lipodermoid.
    • Significant brain malformation, characterized by left hemisphere enlargement, was diagnosed via sonography and computerized tomography.

    Findings:

    • The brain malformation was not associated with cranial or facial bone asymmetry.

    Related Experiment Videos

  • This case highlights a rare association between extensive cutaneous hamartomas and significant intracranial structural abnormalities.

    • Implications:

    • Suggests the need for thorough neuroimaging (computerized tomography and/or ultrasonography) in newborns with extensive linear nevus sebaceous sequence or giant pigmented congenital nevocellular nevus.
    • Early detection of brain malformations can guide timely management and improve patient outcomes.
    • Emphasizes the importance of a multidisciplinary approach in evaluating infants with complex congenital conditions.