One-pot preparation of Mn₃O₄/GSH/CdTe quantum dots complex for T₁-weighted MRI/fluorescence detection of H₃PO₄

Magnetic resonance and fluorescence dual mode imaging with both advantages of high sensitivity and high spatial resolution, which could realize real-time, in situ, and dynamic imaging, is very suitable for detecting small molecules. And the synthesis of imaging materials with good imaging performance has become the core content. In this paper, based on biomimetic mineralization technology, GSH has been used as a material to design a one-pot method for the preparation of Mn₃O₄/GSH/CdTe quantum dots composites (MGQ in short). Furthermore, MGQ with good T₁MR and fluorescence response to the variety concentration of H₃PO₄, has been used for quantitative analysis of H₃PO₄ in serum. And the lowest limit detection could reach 0.1769 nmol/L for fluorescent detection, 0.02207 mol/L for MRI detection. MGQ would be applied as a sensor in diagnostic and clinical applications.