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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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[Role of Complement in Kidney Diseases - New Aspects]
Peter F Zipfel1,2, Svante Zipfel3, Thorsten Wiech4
1Abteilung Infektionsbiologie, Leibniz institut für Naturstoff Forschung und Infektionsbiologie, Jena, Deutschland.
Deutsche Medizinische Wochenschrift (1946)
|May 31, 2023
Summary
The complement system is crucial for immunity and its dysregulation causes kidney disease. New therapies targeting complement are emerging for treating various kidney disorders, including those linked to COVID-19.
Area of Science:
- Immunology
- Nephrology
- Proteolytic cascades
Context:
- The complement system, a key immune component, is intricately linked with coagulation.
- Dysfunctional complement activation and regulation contribute to severe kidney diseases.
- Recent COVID-19 infections highlight complement's role in thrombotic inflammation and kidney damage.
Purpose:
- To review recent advancements in understanding complement's role in kidney diseases.
- To discuss novel complement inhibitors and targeted therapies.
- To focus on specific complement-mediated kidney pathologies and emerging treatments.
Summary:
- This review covers the latest developments in complement's involvement in kidney diseases, including atypical hemolytic uremic syndrome, C3 glomerulopathy, ANCA-associated vasculitis, IgA nephropathy, membranous nephropathy, lupus nephritis, transplant rejection, and COVID-19-associated nephropathy.
- It highlights the growing number of approved and investigational complement inhibitors and therapies.
- The manuscript also touches upon the development of diagnostic guidelines and biomarkers for complement-mediated diseases.
Impact:
- Advances in complement inhibition offer new treatment avenues for severe kidney diseases.
- Emerging therapies show promise for conditions previously lacking effective treatments.
- The development of clinical guidelines and biomarkers will improve diagnosis and management of complement-mediated renal pathologies.
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