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Arrhythmic and thromboembolic outcomes in adults with coarctation of the aorta

John Shadarevian1, Kai Zhu1, Joanne M Kwan1

  • 1Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

International Journal of Cardiology
|May 31, 2023
PubMed

Insights

Adults with coarctation of the aorta (CoA) have a higher rate of atrial arrhythmia (AA) than the general population. Increasing age and intracardiac interventions are linked to AA in these patients.

Area of Science:

  • Cardiology
  • Adult Congenital Heart Disease (ACHD)
  • Vascular Medicine

Background:

  • Adults with congenital heart disease (ACHD) often experience atrial arrhythmia (AA) and thromboembolic events.
  • Data on AA and long-term outcomes in ACHD patients with coarctation of the aorta (CoA) are limited.

Purpose of the Study:

  • To determine the prevalence of AA in adults with CoA.
  • To identify risk factors for AA and thromboembolic complications in adults with CoA.

Main Methods:

  • Retrospective cohort study at a tertiary ACHD care center.
  • Included consecutive CoA patients >18 years old with >1 year follow-up.
  • Followed 270 CoA patients for a mean of 7.2 years.

Main Results:

  • 13% of CoA patients developed AA; 3.8% experienced thromboembolic cerebrovascular events.
  • Increasing age and number of intracardiac interventions were associated with AA.
  • Age, heart failure history, and dyslipidemia were associated with thromboembolism.

Conclusions:

  • AA is more common in adults with CoA compared to the general population, but less common than in other ACHD.
  • Age and intracardiac interventions are significant predictors of AA in CoA patients.
  • Thromboembolic event rates were low; traditional stroke risk factors may be relevant.
Abstract

Keywords:
Aortic coarctationAtrial arrhythmiaCongenital heart diseaseStroke

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