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Related Experiment Video

Updated: Jul 28, 2025

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

Published on: August 24, 2012

Localised Cdr1as activity is required for fear extinction memory.

Esmi Lau Zajaczkowski¹, Qiongyi Zhao¹, Wei-Siang Liau¹

¹Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.

Neurobiology of Learning and Memory

|May 31, 2023

Summary

Circular RNAs (circRNAs) are key brain molecules regulating memory. Targeting cerebellar degeneration-related protein 1 antisense RNA (Cdr1as) in synapses impaired fear extinction memory, showing circRNA

Keywords:

Cdr1as Extinction Fear Memory Synaptosome circRNA

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Extinction Training During the Reconsolidation Window Prevents Recovery of Fear

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Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

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Disrupting Reconsolidation of Fear Memory in Humans by a Noradrenergic β-Blocker

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Published on: December 18, 2014

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Circular RNAs (circRNAs) are stable regulatory molecules found in the brain, especially at synapses.
circRNAs have diverse functions, including microRNA decoy and protein sequestration, and some are translated.
Previous research linked circRNAs to neurological disorders, but their role in memory remains unclear.

Purpose of the Study:

To investigate the role of synaptic circular RNAs in memory formation.
To determine if specific circRNAs are involved in fear extinction memory.

Main Methods:

Analysis of circRNAs in synaptosomes from the medial prefrontal cortex of mice trained in fear extinction.
Identification of synapse-enriched circRNAs, including Cdr1as.
Targeted knockdown of Cdr1as in the infralimbic cortex neural processes.

Main Results:

Identified 12,837 synapse-enriched circRNAs.
Cerebellar degeneration-related protein 1 antisense RNA (Cdr1as) was among the identified circRNAs.
Knockdown of Cdr1as resulted in impaired fear extinction memory.

Conclusions:

Synaptic circRNA plays a crucial role in memory formation.
Cdr1as is implicated in the regulation of fear extinction memory.
Localized circRNA activity at the synapse is vital for memory processes.