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Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
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Human pluripotent stem cell-based models of heart development and disease

Gabriel Velichkova1, Gergana Dobreva2

  • 1Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Cells & Development
|May 31, 2023
PubMed
Summary

This review details advances in directing pluripotent stem cells (PSCs) to form specialized cardiac cell types. It covers progress in cardiac cell specification, maturation, and assembly into functional heart tissues.

Keywords:
Cardiac differentiationCardiac organoidsCardiovascular cell fateESCsHeart-on-a-chiphPSCsiPSCs

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