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Updated: Jul 28, 2025
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
Current Status of Fibroblast Activation Protein Imaging in Gynecologic Malignancy and Breast Cancer
Katharina Dendl1, Stefan A Koerber2, Tadashi Watabe3
1Department of Nuclear Medicine, INF 400, University Hospital Heidelberg, Heidelberg, Germany; Deaprtment of Nuclear medicine, Geb. 13.55, Moorenstraße 5, 40225 Düsseldorf.
Abstract:
68Ga-FAPI-PET/computed tomography (CT) is a novel PET/CT radiotracer particularly developed for oncologic imaging. Gynecologic malignancies comprise a broad spectrum of entities and, along with breast cancer, constitute cancers occurring exclusively or primarily, respectively, in women. Thus, a tracer designed not only for one but multiple malignancies has theoretic attractions. Even in comparison with 18F-FDG, the current standard oncologic tracer of nuclear medicine, 68Ga-FAPI, has demonstrated advantages in several tumors. As breast cancer, ovarian cancer, and cervical cancer are among the most common tumor types in women and are often accompanied by high morbidity as well as mortality rates, a reliable staging tool is paramount for optimal therapeutic management.

