Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

11
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
11
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

10
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
10
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

20
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
20
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

51
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
51
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

30
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
30
Nephrons01:10

Nephrons

3.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left-Sided Weakness in a Kidney Transplant Recipient.

Kidney360·2026
Same author

ASN Kidney Health Guidance on Conservative Management in People with Kidney Failure.

Journal of the American Society of Nephrology : JASN·2026
Same author

The New American Board of Internal Medicine Special Consideration Pilot: Impact on Nephrology and Its International Medical Graduates.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Nephrology Fellows' Cultural Background and Faculty Alignment: A Research Letter.

Kidney medicine·2026
Same author

Transforming Dialysis Access Together Dialysis Access Training: Recommendations for Nephrology Fellows.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

How I Treat Glomerular Diseases in Older Adults.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same journal

Care Transitions Continue to Evolve.

The Medical clinics of North America·2026
Same journal

Navigating the Gaps: A Comprehensive Overview of Care Transitions Across the Continuum.

The Medical clinics of North America·2026
Same journal

Care Transitions and Value-Based Payment Models in the United States.

The Medical clinics of North America·2026
Same journal

Technology and Innovation in Care Transitions: Imagining the Future of Postdischarge Care.

The Medical clinics of North America·2026
Same journal

Primary Care, Specialists, and Hospitals: Bridging the Gaps in Communication and Coordination.

The Medical clinics of North America·2026
Same journal

Social Determinants of Health: Unique Considerations in Transitions of Care.

The Medical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jul 28, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.5K

Nephrotic Syndrome for the Internist.

Maria Jose Zabala Ramirez1, Eva J Stein1, Koyal Jain1

  • 1Division of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill, 7024 Burnett Womack Building, CB 7155, Chapel Hill, NC 27599, USA.

The Medical Clinics of North America
|May 31, 2023
PubMed
Summary
This summary is machine-generated.

Nephrotic syndrome (NS) is a kidney disorder causing protein loss, edema, and hypoalbuminemia due to glomerular damage. Understanding its diverse causes is crucial for internists to guide patient evaluation and management effectively.

Keywords:
EdemaGlomerulonephritisHypoalbuminemiaNephrotic syndromeNephrotic syndrome/complicationsNephrotic syndrome/managementNephrotic syndrome/pathophysiologyProteinuria

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

643

Related Experiment Videos

Last Updated: Jul 28, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.5K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

643

Area of Science:

  • Nephrology
  • Internal Medicine
  • Pathophysiology

Background:

  • Nephrotic syndrome (NS) is a significant clinical condition requiring internist recognition.
  • It presents with proteinuria, edema, and hypoalbuminemia.
  • NS results from increased glomerular permeability, allowing protein leakage into urine.

Purpose of the Study:

  • To review clinically important etiologies of nephrotic syndrome.
  • To guide internists in the initial clinical evaluation of NS.
  • To enhance understanding of the underlying causes driving nephrosis.

Main Methods:

  • Literature review of clinically relevant nephrotic syndrome etiologies.
  • Synthesis of information on infectious, metabolic, malignant, and autoimmune causes.
  • Focus on factors informing initial clinical assessment.

Main Results:

  • Nephrotic syndrome stems from diverse underlying conditions.
  • Proteinuria triggers complications like fluid retention, inflammation, and immune dysregulation.
  • Recognizing varied etiologies is key for effective patient management.

Conclusions:

  • A comprehensive understanding of nephrotic syndrome causes is essential for internists.
  • Initial evaluation should consider a broad differential diagnosis.
  • Effective management hinges on identifying the specific etiology driving the syndrome.