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Ferrets as Models for Viral Respiratory Disease.
Rachel E Smith, Shambhunath Choudhary, Julita A Ramirez1
1Pfizer Worldwide Research, Development & Medical, Pearl River, New York 10965, USA;,
Comparative Medicine
|May 31, 2023
Summary
Domestic ferrets are valuable biomedical models for studying respiratory viruses like influenza and COVID-19. This review covers essential ferret biology and management for accurate and reproducible research.
Area of Science:
- Veterinary Medicine
- Comparative Pathology
- Animal Models
Background:
- Domestic ferrets (Mustela putorius furo) have a long history in influenza research.
- Their susceptibility and anatomical similarities to humans make them ideal for studying viral respiratory diseases.
- This review focuses on considerations for using ferrets in respiratory disease models.
Approach:
- Discusses key aspects of ferret biology and management relevant to research.
- Covers biosafety, husbandry, clinical and pathological assessments, and anesthesia.
- Reviews ferret respiratory anatomy and their use in studying influenza and COVID-19.
Key Points:
- Proper management ensures animal welfare and model fidelity.
- Anesthetic considerations are crucial for ferrets with respiratory or systemic illness.
- Accurate data collection relies on understanding ferret-specific needs.
Conclusions:
- Ferrets are critical animal models for understanding human respiratory viral infections.
- Considerations for ferret biology and management enhance research reproducibility.
- This review provides essential guidance for researchers working with ferrets.
