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Evaluation and Management of Bing-Neel Syndrome
Sarah J Schep1, Josephine M I Vos2, Monique C Minnema3
1Department of Hematology, HAGA Ziekenhuis, Els Borst-Eilersplein 275, 2545 AA The Hague, The Netherlands.
Abstract:
Bing-Neel syndrome is a rare manifestation of Waldenström macroglobulinemia (WM), which is caused by infiltration of the malignant lymphoplasmacytic cells in the central nervous system. Patients can present with a diverse range of neurologic symptoms, and differentiation with other comorbidities seen in WM, such as immunoglobulin M-related polyneuropathy, can be challenging. Both the rarity of this disorder and the heterogeneity of the clinical presentation often cause a significant diagnostic delay with the risk of permanent neurologic damage. This review summarizes current knowledge regarding diagnosis, treatment and prognosis of Bing-Neel syndrome.
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