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Prevalence of LDL-hypercholesterolemia and other cardiovascular risk factors in young people with type 1 diabetes

Irena Drozd1, Jantje Weiskorn2, Karin Lange3

  • 1Children's Hospital AUF DER BULT, Janusz-Korczak-Allee 12, Hannover 30173, Germany; Medical Psychology, Hannover Medical School, Hannover, Germany.

Journal of Clinical Lipidology
|May 31, 2023
PubMed

Insights

Nine percent of youth with Type 1 diabetes (T1D) have LDL-hypercholesterolemia, a condition linked to other cardiovascular risk factors (CVRFs). Early intervention and a comprehensive treatment approach are crucial for managing CVRFs in young individuals with T1D.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a primary cause of mortality and morbidity in individuals with Type 1 diabetes (T1D).
  • Early identification and management of cardiovascular risk factors (CVRFs) are critical for mitigating long-term health complications in youth with T1D.

Purpose of the Study:

  • To determine the prevalence of LDL-hypercholesterolemia and other CVRFs in pediatric and adolescent populations diagnosed with T1D.
  • To identify associations between LDL-hypercholesterolemia and other CVRFs in this demographic.

Main Methods:

  • A cohort of 333 youth (ages 6-18) with T1D duration exceeding one year was evaluated.
  • Data collected included clinical and laboratory parameters, and intima-media thickness measurements.
  • Cardiovascular risk factors defined as LDL-hypercholesterolemia, microalbuminuria, and arterial hypertension.

Main Results:

  • LDL-hypercholesterolemia was identified in 9% of the study participants (30 individuals).
  • LDL-hypercholesterolemia was significantly associated with increased blood pressure, insulin requirements, HbA1c levels, triglycerides, total cholesterol, and a family history of premature CVD.
  • Arterial hypertension was present in 3.3% of participants, and 18.3% showed elevated albumin excretion in random urine samples.

Conclusions:

  • LDL-hypercholesterolemia is a prevalent CVRF in youth with T1D, often co-existing with other risk factors.
  • A comprehensive, holistic therapeutic strategy is essential for managing cardiovascular risks in young individuals with T1D.
Abstract

Keywords:
AdolescentsCardiovascular risk factorsChildrenDyslipidemiaPreventionType 1 diabetescIMT

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