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[Structure-release relationship of physical polymer/drug combinations. 2. Diffusion of 3-methylpyrazole through a
Die Pharmazie
|February 1, 1986
Abstract:
The diffusion of 3-methylpyrazole through a synthetic polymer matrix and the effect of the solubility of the bioactive agent in polymers on the release behaviour of polymer combinations were studied. With increasing hydrophilicity of the polymer both the diffusion and the diffusion coefficient of 3-methylpyrazole increased and the solubility of the agent in the polymer decreased. The hydrophilicity of various polymers is discussed on the basis of a parameter determined by turbidimetric titrations.