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Related Experiment Video

Updated: Jul 28, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

A versatile bioelectronic interface programmed for hormone sensing.

Preetam Guha Ray¹, Debasis Maity¹, Jinbo Huang¹

¹ETH Zurich, Department of Biosystems Science and Engineering, Mattenstrasse 26, CH-4058, Basel, Switzerland.

Nature Communications

|May 31, 2023

Summary

This summary is machine-generated.

A new versatile bioelectronic interface (VIBE) precisely profiles peptide hormones like insulin and GLP-1 at low concentrations. This technology differentiates diabetic mouse models and human metabolic states for personalized medicine.

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Personalized Medicine

Background:

Precision medicine demands ultrasensitive, real-time bio-analyte profiling for optimized healthcare.
Current methods for hormone level detection can be limited in sensitivity and real-time capabilities.

Purpose of the Study:

To develop and validate a versatile bioelectronic interface (VIBE) for sensitive detection of receptor-ligand interactions.
To demonstrate VIBE's capability in profiling peptide hormones and differentiating disease states.

Main Methods:

Fabrication of a versatile bioelectronic interface (VIBE).
Detection of receptor-ligand interactions through electronic signal changes.
Quantification of peptide hormones (insulin, GLP-1) in biological samples.

Main Results:

VIBE achieved a low detection limit in the sub-nanomolar range.
The interface precisely profiled peptide hormones across physiologically relevant concentrations.
VIBE successfully differentiated insulin and GLP-1 levels in serum from wild-type and diabetic mice.
Human serum samples showed differentiation between individuals and metabolic states.

Conclusions:

VIBE provides a sensitive and precise platform for bio-analyte detection.
The technology shows potential for point-of-care diagnostics and personalized medicine.
The adaptable nature of VIBE allows for detection of various analytes by changing engineered cells.