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Updated: Jul 28, 2025
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
In Silico Structure-Based Vaccine Design
Sakshi Piplani1, David Winkler2,3,4, Yoshikazu Honda-Okubo1
1Vaxine Pty Ltd, Adelaide, SA, Australia.
Abstract:
Structure-based vaccine design (SBVD) is an important technique in computational vaccine design that uses structural information on a targeted protein to design novel vaccine candidates. This increasing ability to rapidly model structural information on proteins and antibodies has provided the scientific community with many new vaccine targets and novel opportunities for future vaccine discovery. This chapter provides a comprehensive overview of the status of in silico SBVD and discusses the current challenges and limitations. Key strategies in the field of SBVD are exemplified by a case study on design of COVID-19 vaccines targeting SARS-CoV-2 spike protein.
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