Related Experiment Video
Updated: Jul 28, 2025
In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
Local Drug Delivery Techniques for Triggering Immunogenic Cell Death
En Ren1, Yanfang Wang1, Tingxizi Liang1
1Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Abstract:
Immunogenic cell death (ICD), a dying state of the cells, encompasses the changes in the conformations of cell surface and the release of damage-associated molecular patterns, which could initiate an adaptive immune response by stimulating the dendritic cells to present antigens to T cells. Advancements in biomaterials, nanomedicine, and micro- and nano-technologies have facilitated the development of effective ICD inducers, but the potential toxicity of these vesicles encountered in drug delivery via intravenous administration hampers their further application. As alternatives, the local drug delivery systems have gained emerging attention due to their ability to prolong the retention of high payloads at the lesions, sequester drugs from harsh environments, overcome biological barriers to exert optimal efficacy, and minimize potential side effects to guarantee bio-safety. Herein, a brief overview of the local drug delivery techniques used for ICD inducers is provided, explaining how these techniques broaden, alter, and enhance the therapeutic capability while circumventing systemic toxicity at the same time. The historical context and prominent examples of the local administration of ICD inducers are introduced. The complexities, potential pitfalls, and opportunities for local drug delivery techniques in cancer immunotherapy are also discussed.
Insights
Local drug delivery systems offer a safer alternative for cancer immunotherapy by enhancing immunogenic cell death (ICD) inducers. These systems improve drug retention and efficacy while minimizing systemic toxicity.
Area of Science:
- Oncology
- Immunology
- Biomaterials Science
Background:
- Immunogenic cell death (ICD) is a cellular process that triggers adaptive immune responses crucial for cancer immunotherapy.
- Current ICD inducers, often delivered intravenously, face limitations due to potential systemic toxicity.
- Local drug delivery systems present a promising alternative to overcome these limitations.
Purpose of the Study:
- To provide an overview of local drug delivery techniques for immunogenic cell death (ICD) inducers.
- To explain how local delivery enhances therapeutic capabilities and circumvents systemic toxicity.
- To discuss the complexities, pitfalls, and opportunities of local drug delivery in cancer immunotherapy.
Main Methods:
- Review of existing literature on local drug delivery systems for ICD inducers.
- Analysis of historical context and prominent examples of local administration of ICD inducers.
- Discussion of the advantages and challenges associated with local drug delivery strategies.
Main Results:
- Local drug delivery systems can prolong drug retention at tumor sites.
- These systems effectively sequester drugs, overcome biological barriers, and optimize therapeutic efficacy.
- Local administration minimizes systemic side effects, enhancing patient safety and bio-safety.
Conclusions:
- Local drug delivery represents a significant advancement in cancer immunotherapy by improving ICD inducer efficacy and safety.
- These techniques offer a viable strategy to enhance anti-tumor immune responses while mitigating off-target toxicities.
- Further research into local drug delivery holds substantial promise for optimizing cancer treatment outcomes.
More Related Videos
09:18Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
07:04Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
Related Concept Videos
01:27Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
01:17The Extrinsic Apoptotic Pathway
01:30Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
01:27Tumor Immunotherapy
01:22Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
01:28Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...