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Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Rachna M Kumar1, Hitesh Kumar1, Tanvi Bhatt1

  • 1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570015, India.

Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
PubMed

Insights

Fisetin, a natural compound, shows promise for cancer treatment due to its anticancer properties. However, poor bioavailability necessitates nanomedicine formulations for effective clinical use.

Area of Science:

  • Oncology
  • Pharmacology
  • Nanomedicine

Background:

  • Cancer is a leading global cause of mortality, characterized by cell invasion and metastasis.
  • Fisetin, a natural flavone, exhibits antioxidant, anti-inflammatory, antiangiogenic, and anticancer properties.
  • Fisetin inhibits tumor growth, invasiveness, and metastasis by hindering cancer cell multiplication and inducing apoptosis.

Purpose of the Study:

  • To review fisetin's potential as an anticancer therapeutic agent.
  • To discuss fisetin's pharmacological properties relevant to cancer treatment.
  • To explore nanomedicine formulation strategies for improving fisetin delivery.

Main Methods:

  • Literature review of fisetin's anticancer mechanisms and properties.
  • Analysis of fisetin's pharmacokinetic challenges, including poor bioavailability and hydrophobicity.
  • Exploration of nanomedicine approaches like liposomes and nanocochleates for fisetin formulation.

Main Results:

  • Fisetin demonstrates significant anticancer effects by inhibiting cancer cell proliferation and promoting apoptosis via caspase pathways.
  • Poor bioavailability and hydrophobicity limit fisetin's clinical application.
  • Nanomedicine strategies offer potential solutions to enhance fisetin delivery and efficacy.

Conclusions:

  • Fisetin is a promising natural compound for anticancer therapy.
  • Overcoming bioavailability limitations through nanomedicine is crucial for its clinical translation.
  • Further research into fisetin-loaded nanocarriers can optimize its therapeutic potential.
Keywords:
cancerfisetinflavonoidsnanocarrierphytoconstituent

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