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Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges
Qiao Luo1, Ni Shao1, Ai-Chen Zhang1
1The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Pharmaceuticals (Basel, Switzerland)
|June 1, 2023
Summary
Nanozymes offer advanced molecular imaging for disease diagnosis by mimicking enzyme activity. These nanomaterials enhance imaging accuracy and enable image-guided therapies for conditions like cancer and infections.
Area of Science:
- Biomedical Nanotechnology
- Molecular Imaging
- Nanomedicine
Background:
- Nanozymes are emerging nanoplatforms with enzyme-like catalytic activities.
- They possess unique properties like biocompatibility, surface tenability, and cost-effectiveness.
- Nanozymes are increasingly utilized in molecular imaging for disease diagnosis.
Purpose of the Study:
- To review the applications of nanozymes in molecular imaging.
- To discuss specific nanozyme types (POD, OXD, CAT, SOD) and their imaging modalities.
- To explore nanozyme applications in image-guided therapy for cancer, infections, and inflammation.
Main Methods:
- Integration of nanoparticles with diverse imaging properties (superparamagnetic, photoacoustic, fluorescence, photothermal).
- Utilizing nanozymes' enzyme-mimicking activities for enhanced imaging sensitivity and accuracy.
- Reviewing literature on nanozyme applications in disease diagnosis and therapy.
Main Results:
- Nanozymes improve molecular imaging sensitivity and accuracy by combining catalytic activity with multimodal imaging properties.
- Specific nanozymes like peroxidase, oxidase, catalase, and superoxide dismutase show promise in various imaging modalities.
- Nanozymes demonstrate potential as therapeutic agents for image-guided treatment of diseases.
Conclusions:
- Nanozymes represent a versatile platform for advanced molecular imaging and theranostics.
- Further research and clinical translation of biomimetic nanozymes are crucial for advancing nanomedicine.
- This review provides a comprehensive reference for nanozyme applications in molecular imaging and therapy.
