Intranasal Lipid Nanoparticles Containing Bioactive Compounds Obtained from Marine Sources to Manage...

Area of Science:

• Marine biotechnology
• Neuroscience
• Nanotechnology

Background:

• Marine sources possess bioactive compounds with antioxidant properties beneficial for neurodegenerative diseases.
• Marine bio-waste is a sustainable source for natural antioxidants, offering an alternative to synthetic compounds.
• Overcoming the blood-brain barrier (BBB) is a major challenge for treating neurodegenerative diseases.

Purpose of the Study:

• To review the use of lipid nanoparticles for delivering bioactive compounds from marine bio-waste.
• To explore the potential of intranasal administration for treating neurodegenerative diseases.
• To highlight the application of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in this context.

Main Methods:

• Review of in vitro and in vivo studies on SLN and NLC for intranasal delivery.
• Analysis of bioactive compounds derived from marine bio-waste.
• Investigation of nose-to-brain transport mechanisms.

Main Results:

• Intranasal delivery of SLN and NLC shows promise for transporting bioactive compounds to the central nervous system (CNS).
• These systems bypass the BBB, enabling direct nose-to-brain transport.
• Studies indicate relevant outcomes for treating neurodegenerative diseases.

Conclusions:

• Lipid nanoparticles (SLN and NLC) are effective delivery systems for marine bioactive compounds via intranasal administration.
• This approach holds significant potential for treating neurodegenerative diseases by overcoming BBB limitations.
• Further research into marine bio-waste as a source for these therapies is warranted.