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Racial, Ethnic, and Sex-based Disparities among High-risk Individuals Undergoing Pancreatic Cancer Surveillance
Bryson W Katona1, Kelsey Klute2, Randall E Brand3
1University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Cancer Prevention Research (Philadelphia, Pa.)
|June 1, 2023
Summary
The PRECEDE study found significant racial/ethnic and sex disparities in pancreatic cancer surveillance enrollment. Future efforts will focus on increasing diversity in high-risk individual recruitment for pancreatic ductal adenocarcinoma surveillance.
Area of Science:
- Oncology
- Epidemiology
- Clinical Research
Background:
- Pancreatic cancer surveillance is crucial for reducing mortality.
- The Pancreatic Cancer Early Detection (PRECEDE) Consortium aims to enroll high-risk individuals (HRIs) for pancreatic ductal adenocarcinoma (PDAC) surveillance.
- Evaluating enrollment disparities is essential for equitable study participation.
Purpose of the Study:
- To assess racial/ethnic and sex-based disparities in the enrollment of HRIs in the PRECEDE Consortium.
- To identify demographic characteristics of enrolled participants.
- To inform future strategies for more diverse participant recruitment.
Main Methods:
- Analysis of data from 1,113 eligible HRIs enrolled in the PRECEDE Consortium between May 2020 and March 2022.
- Inclusion criteria included meeting guideline-based criteria for PDAC surveillance.
- Data collected on demographics, familial history, genetic variants, and consent for research utilization.
Main Results:
- The majority of participants were from the United States (82.7%), aged 60-69 years (37.4%), and female (65.9%).
- Significant racial/ethnic disparities were observed, with 87.7% self-reporting as white and only 2.9% as Hispanic.
- Consent rates for research utilization of data and biosamples were uniform across all demographic subgroups.
Conclusions:
- Substantial racial/ethnic and sex-based disparities persist in the enrollment of HRIs for PDAC surveillance.
- Ensuring diversity in surveillance programs is critical to mirror the populations served.
- Reducing these enrollment disparities will be a key focus for the PRECEDE Consortium moving forward.
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