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Updated: Jul 28, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
A bottleable super-electron-donor for catalytic borylation of aryl halides
Wenbo Ming1,2, Yashi Xu1, Libo Xiang3,4
1Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Abstract:
[(Dpp-bian)B(DMAP)]2 (dpp-bian = 1,2-bis[(2,6-diisopropylphenyl)imino]acenaphthene, DMAP = 4-(dimethylamino)pyridine), a bottleable super electron donor (SED), was demonstrated to serve as a SED catalyst in the borylation of aryl iodides, bromides, and the more challenging chlorides. Apart from installing Bpin from B2pin2, the SED-catalyzed borylation protocol is also applicable for installing Bdan from Bpin-Bdan. The radical mechanism has been confirmed by the radical trapping and radical clock experiments.
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