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Relationship of Serum Periostin With Asthma Control in Children: Single Center Experience
Sarita Choudhary1, Prawin Kumar1, Mithu Banerjee2
1Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan.
Insights
Serum periostin levels are elevated in children with asthma. Higher periostin levels correlate with poorer asthma control, indicating its potential as a biomarker for disease management.
Area of Science:
- Pediatric Pulmonology
- Biomarkers
- Asthma Research
Background:
- Asthma is a chronic respiratory disease affecting millions of children worldwide.
- Effective asthma control is crucial for maintaining quality of life and preventing exacerbations.
- Identifying reliable biomarkers for asthma control is an ongoing area of research.
Purpose of the Study:
- To investigate the association between serum periostin levels and asthma control in pediatric patients.
- To determine if periostin can serve as a predictive marker for asthma control status.
Main Methods:
- A study cohort included 60 children aged 6-17 years diagnosed with asthma and 30 age-matched healthy controls.
- Serum periostin levels were measured and compared between asthmatic children and controls.
- Multivariable logistic regression analysis was employed to assess the relationship between periostin levels and asthma control.
Main Results:
- Children with asthma exhibited significantly higher median serum periostin levels compared to control subjects (P=0.04).
- Elevated serum periostin levels were found to be significantly associated with poor asthma control in children (P=0.02).
- Factors such as age, BMI, IgE, eosinophil count, FEV1, and allergic rhinitis showed no significant association with asthma control.
Conclusions:
- Asthmatic children generally present with higher serum periostin levels.
- Increased serum periostin levels are linked to diminished asthma control in pediatric populations.
- Periostin may represent a valuable biomarker for assessing asthma control in children.
Objective:
To determine the association between serum periostin levels and asthma control in children.
Methods:
Children aged 6-17 years with physician-diagnosed asthma were enrolled in the study. Age-matched (±2 years) control children, who visited our outpatient department with non-respiratory complaints, were also enrolled.
Results:
A total of 90 children (60 with asthma and 30 control subjects) with a mean (SD) age of 12.1 (2.77) years were enrolled. Children with asthma had significantly higher median (IQR) periostin levels than the controls [23.5 (22,26) vs 22 (19.4, 22.96); P= 0.04]. On multivariable logistic regression analysis, serum periostin levels were associated with poor asthma control in children [OR (95% CI), 1.12 (1.01-1.24); P= 0.02]. Age, body mass index, IgE levels, eosinophil count, forced expiratory volume in first minute (FEV1) and presence of allergic rhinitis did not have any association with asthma control.
Conclusion:
Asthmatic children have a high serum periostin level, and its higher levels are associated with poor asthma control.
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