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Palmitoylation in apoptosis.

Peiyao Li1, Xiaoyi Gong1, Lei Yuan1

  • 1Department of Cell and Development Biology, College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Journal of Cellular Physiology
|June 1, 2023
PubMed
Summary
This summary is machine-generated.

Palmitoylation, a protein modification, influences cell death pathways like apoptosis. This review explores how palmitoylation impacts apoptosis in various human diseases.

Keywords:
apoptosisdeacyltransferasespalmitoylationpalmitoyltransferasesprotein modification

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Palmitoylation is a critical lipid modification affecting protein localization, transport, and stability.
  • S-palmitoylation is a reversible modification catalyzed by palmitoyltransferases and reversed by deacyltransferases.
  • Apoptosis, a programmed cell death, is crucial for homeostasis and implicated in immune and inflammatory diseases.

Purpose of the Study:

  • To review the intricate relationship between palmitoylation modifications and apoptosis.
  • To highlight the role of palmitoylation in the context of apoptosis across various human diseases.

Main Methods:

  • Literature review of recent studies on palmitoylation and apoptosis.
  • Analysis of the molecular mechanisms linking protein palmitoylation to apoptotic pathways.

Main Results:

  • Palmitoylation plays a significant role in regulating apoptosis.
  • Dysregulation of palmitoylation is associated with altered apoptotic processes in disease.

Conclusions:

  • Palmitoylation is a key regulator of apoptosis.
  • Understanding palmitoylation's role in apoptosis offers potential therapeutic targets for diseases involving aberrant cell death.