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Updated: Jul 28, 2025
07:22
Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
Published on: December 1, 2023
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Lymphoma recurrence presenting as vocal cord fixation.
Carter M Denne1, Stephen Schell1, Andrew Steehler1
1Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center-Hamot Hospital, Erie, PA, USA.
Ear, Nose, & Throat Journal
|June 1, 2023
Summary
Laryngeal lymphoma, a rare condition, can cause hoarseness and dysphagia. This case highlights a diffuse large B-cell lymphoma (DLBCL) recurrence in the larynx, successfully treated with chemotherapy.
Area of Science:
- Oncology
- Otorhinolaryngology
- Hematology
Background:
- Lymphomas of the larynx are uncommon neoplasms.
- Laryngeal lymphoma often manifests with symptoms including vocal hoarseness, throat pain, dysphagia, and weight loss.
Purpose of the Study:
- To report a case of laryngeal lymphoma recurrence.
- To emphasize the importance of considering lymphoma in patients with laryngeal symptoms, particularly those with a prior history of lymphoma.
Main Methods:
- A 74-year-old male patient presented with new-onset hoarseness and dysphagia.
- Nasolaryngoscopy revealed a large, right-sided submucosal mass with vocal cord fixation.
- Biopsy confirmed recurrent diffuse large B-cell lymphoma (DLBCL) isolated to the larynx.
Main Results:
- The patient had a history of DLBCL but was in remission.
- Physical examination and CT scan did not reveal adenopathy.
- Treatment with chemotherapy resulted in full recovery of vocal cord motion and resolution of symptoms.
Conclusions:
- Recurrent DLBCL can present as an isolated laryngeal mass.
- Laryngeal complaints in patients with a history of lymphoma warrant a high suspicion for lymphoma recurrence.
- Prompt diagnosis and treatment, such as chemotherapy, can lead to favorable outcomes.
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