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Revitalizing myocarditis treatment through gut microbiota modulation: unveiling a promising therapeutic avenue

Jingyue Wang1,2, Xianfeng Zhang3, Xinyu Yang1,2

  • 1Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, China.

Frontiers in Cellular and Infection Microbiology
|June 1, 2023
PubMed

Insights

Emerging research links gut microbiota to myocarditis, an inflammatory heart condition. Targeting gut bacteria may offer new therapeutic strategies for this growing concern.

Area of Science:

  • Cardiology
  • Microbiology
  • Immunology

Background:

  • Gut microbiota significantly influences cardiovascular diseases, including hypertension and atherosclerosis.
  • Recent evidence implicates gut microbiota in the pathogenesis of myocarditis, an inflammatory heart condition causing myocardial damage.
  • Myocarditis is a growing concern, particularly in young adults, and is linked to COVID-19 and vaccinations, yet therapeutic options remain limited.

Purpose of the Study:

  • To review the gut-heart axis, gut microbiota-immune system interactions, and the association between myocarditis and the immune system.
  • To explore the impact of gut microbiota and its metabolites on myocarditis development.
  • To discuss current gut microbiota modulation strategies and future directions for targeting gut microbiota in myocarditis treatment.

Main Methods:

  • Literature review focusing on the gut-heart axis.
  • Analysis of studies linking gut microbiota, immune system, and myocarditis.
  • Examination of therapeutic strategies for modulating gut microbiota.

Main Results:

  • The gut-heart axis is a complex interplay influencing cardiovascular health.
  • Gut microbiota and immune system dysregulation are implicated in myocarditis.
  • Modulating gut microbiota presents a potential, yet underdeveloped, therapeutic avenue for myocarditis.

Conclusions:

  • Targeting the gut microbiota-immune system-myocarditis axis offers a novel approach for myocarditis treatment.
  • Further research is needed to establish gut microbiota as a viable therapeutic target for myocarditis.
  • This review highlights the potential of gut microbiota modulation for managing myocarditis and its complications.

Keywords:
gut microbiotaimmune systemmetabolitesmyocarditistreatment

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