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Pseudo-multicomponent reactions.

Julio C Flores-Reyes¹, Vanesa Del C Cotlame-Salinas¹, Ilich A Ibarra²

¹Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa Av. Ferrocarril San Rafael Atlixco 186, Col. Leyes de Reforma 1A Sección, Iztapalapa Ciudad de México C.P. 09310 Mexico egz@xanum.uam.mx aij@xanum.uam.mx.

|June 1, 2023

Summary

This review explores pseudo-multicomponent reactions (pseudo-MCRs), a synthetic strategy using repeated reactants to create complex molecules. These reactions offer efficient pathways to diverse chemical libraries and symmetrical compounds.

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Published on: April 4, 2014

Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Multicomponent reactions (MCRs) are one-pot syntheses combining multiple reactants.
Pseudo-MCRs involve reactants participating in multiple steps or having multiple functional groups.
Pseudo-MCRs offer efficient synthesis of complex molecules with potential for high symmetry.

Purpose of the Study:

To review recent advancements in pseudo-MCRs and their repetitive variants.
To highlight the synthesis of novel, complex, and highly symmetrical molecules.
To showcase applications of pseudo-MCRs in science and technology.

Main Methods:

Literature review focusing on publications from the last two decades.
Categorization of pseudo-MCRs based on the number of participating reagents.
Analysis of reaction mechanisms and product structures.

Main Results:

Pseudo-MCRs enable the creation of diverse compound libraries in few steps.
Repetitive pseudo-MCRs allow for the synthesis of highly symmetrical molecules.
These reactions are valuable tools for generating complex molecular architectures.

Conclusions:

Pseudo-MCRs are powerful synthetic methodologies for accessing complex and symmetrical compounds.
The review provides insights into the scope and potential of pseudo-MCRs for future research.
Applications span various scientific and technological fields.