Proton pump inhibitors and dementia: what association?
Catarina Caetano1, Marta Veloso1, Susana Borda1
1Unidade de Saúde Familiar Delta, Administração Regional de Saúde de Lisboa e Vale do Tejo, Oeiras, Lisboa, Portugal.
Abstract:
Several recent studies have suggested an association between proton pump inhibitors and the development of cognitive changes.
Objective:
To assess the existence of this association.
Methods:
A comprehensive literature search was conducted including guidelines, meta-analyses, systematic reviews, observational and experimental studies published between February 2011 and February 2021.
Results:
The initial research identified 393 articles, 28 of which were included: 8 systematic reviews, 1 clinical trial, 15 observational studies, 3 case-control studies, and 1 cross-sectional observational study.
Conclusions:
Most studies classified with the highest level of evidence found no statistically significant association between the use of proton pump inhibitors and the development of cognitive impairment or dementia.
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