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Related Experiment Videos

Periventricular leukomalacia: evaluation with MR imaging.

D A Wilson, R E Steiner

    Radiology
    |August 1, 1986
    PubMed
    Summary

    Magnetic resonance (MR) imaging revealed abnormalities in all infants with periventricular leukomalacia. Specific MR findings, including white matter lesions and delayed myelination, correlated with poor patient outcomes.

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    Area of Science:

    • Neuroimaging
    • Pediatric Neurology
    • Neuroradiology

    Background:

    • Periventricular leukomalacia (PVL) is a common cause of neurological impairment in preterm infants.
    • Ultrasound is typically used for initial diagnosis, but its limitations in visualizing white matter abnormalities exist.

    Purpose of the Study:

    • To evaluate the utility of magnetic resonance (MR) imaging in characterizing periventricular leukomalacia (PVL) in infants.
    • To correlate MR findings with neurodevelopmental outcomes.
    • To assess the role of MR imaging in monitoring disease progression.

    Main Methods:

    • Retrospective review of 24 MR images from 12 infants diagnosed with PVL via ultrasound.
    • Categorization of MR findings: white matter lesions, ventriculomegaly/atrophy, and myelination status.
    • Comparison of follow-up MR examinations for six patients.

    Main Results:

    • All 12 infants showed abnormalities on MR imaging.
    • Key findings associated with poor outcomes included extensive white matter lesions, delayed myelination, lack of myelination progression, and significant cortical atrophy.
    • MR imaging effectively depicted myelination extent and progression.

    Conclusions:

    • MR imaging is a valuable tool for detailed assessment of PVL, offering more comprehensive information than ultrasound.
    • Specific MR imaging findings can predict neurodevelopmental outcomes in infants with PVL.
    • MR imaging facilitates long-term follow-up of PVL patients, even after fontanel closure.

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