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Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
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T-cell senescence induced by peripheral phospholipids.
Mingyue Ma1, Ying Yang2, Zhouyi Chen3
1Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Cell Biology and Toxicology
|June 1, 2023
Summary
Aging alters immune cells and lipid metabolism, with phospholipids impacting T-cell senescence. Understanding this immune-metabolic crosstalk is key for age-related disease therapies.
Area of Science:
- Immunology
- Metabolomics
- Gerontology
Background:
- Immune cell function and lipid metabolism are dynamically linked.
- Age-related changes in circulating immune cells and lipid metabolites are not fully understood.
Purpose of the Study:
- To investigate the interplay between systemic lipid metabolism and circulating immune cells across different age groups.
- To explore how immune cell phenotype and function are influenced by the peripheral lipid environment.
- To identify metabolic and immune changes associated with aging and cancer.
Main Methods:
- Integrated analysis of clinical measurements, immune cells, and plasma lipidomics in 2000 individuals.
- In-depth analysis of immune cell phenotype and function in relation to lipid profiles.
- Mouse model studies to assess the impact of dietary phospholipids on T-cell senescence.
Main Results:
- A significant shift in immune cell populations and lipid metabolites was observed between young and middle-aged groups, with elevated phospholipids correlating with immune response.
- Dietary phospholipids induced T-cell senescence in a mouse model.
- Cancer patients exhibited distinct lipid profiles, including increased cholesteryl esters and decreased free fatty acids, altering the typical metabolism-immunity crosstalk.
Conclusions:
- Immune senescence is interconnected with systemic metabolism, highlighting the importance of a systems-level approach for immune-metabolic targeting.
- Age-related immune and metabolic changes provide potential targets for therapeutic interventions, such as metabolic drugs to modulate immune activity.
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