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Updated: May 1, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

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Evaluation of the Cherokee Nation Hepatitis C Virus Elimination Program - Cherokee Nation, Oklahoma, 2015-2020

Whitney Essex, Molly Feder, Jorge Mera

    MMWR. Morbidity and Mortality Weekly Report
    |June 1, 2023
    PubMed

    Insights

    Cherokee Nation

    Area of Science:

    • Public Health
    • Infectious Diseases
    • Hepatology

    Background:

    • Hepatitis C virus (HCV) disproportionately affects American Indian/Alaska Native populations.
    • Cherokee Nation Health Services (CNHS) launched an HCV elimination program in 2015.
    • The program aimed to reduce HCV infection rates through screening, workforce expansion, and harm reduction.

    Purpose of the Study:

    • To evaluate the progress of the CNHS HCV elimination program 5 years after its initiation.
    • To assess HCV diagnosis, linkage to care, treatment initiation, and sustained virologic response (SVR) rates.

    Main Methods:

    • Analysis of deidentified health records from November 1, 2015, to October 31, 2020.
    • Inclusion of 1,423 individuals diagnosed with HCV infection.
    • Tracking of linkage to care, treatment initiation, and SVR12 confirmation.

    Main Results:

    • 1,423 individuals diagnosed with HCV infection.
    • 86.2% linked to HCV care.
    • 61.2% initiated HCV treatment, with 49.1% achieving SVR12.
    • 99.4% cure rate among those completing treatment and attending SVR12 visit.

    Conclusions:

    • CNHS successfully linked most diagnosed individuals to care.
    • Treatment initiation rates were lower than anticipated.
    • Future efforts must address treatment initiation gaps and ensure SVR12 confirmation.

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