Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The role of hemoadsorption in septic shock: toward a personalized approach.

Critical care (London, England)·2026

Same author

Artificial Liver Support Effectively Removes Immunosuppressive Bile Acids From Circulation in Patients With Severe Liver Failure: A Proof of Concept Study.

Critical care explorations·2026

Same author

Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026

Same author

Effects of hemoadsorption on plasma catecholamine levels: an in vitro study.

Scientific reports·2026

Same author

Con: we should fully utilise the preload reserve in high-risk patients undergoing noncardiac surgery.

European journal of anaesthesiology·2026

Same author

Impaired tissue perfusion in high-risk patients having major abdominal surgery: a multicenter observational study.

Critical care (London, England)·2026

Search research articles

Related Experiment Video

Updated: Jul 28, 2025

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

Hemoperfusion with CytoSorb®: Current Knowledge on Patient Selection, Timing, and Dosing.

Gerd Klinkmann^1,2, Sebastian Koball³, Daniel A Reuter¹

¹Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University of Rostock, Rostock, Germany.

Contributions to Nephrology

|June 1, 2023

Summary

Early and intense use of CytoSorb® in septic shock patients, when carefully selected, improves survival. These recommendations require further clinical validation for optimal patient outcomes.

More Related Videos

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Related Experiment Videos

Last Updated: Jul 28, 2025

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

Published on: June 14, 2024

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Critical Care Medicine
Medical Technology
Sepsis Management

Background:

Direct hemoperfusion with CytoSorb® is used in critical care for sepsis and multiorgan failure.
Clinical outcomes and usage parameters for CytoSorb® vary significantly.
Evidence-based treatment recommendations are needed.

Purpose of the Study:

To provide an overview of current treatment recommendations for CytoSorb® in septic shock.
To identify clinical usage parameters impacting patient outcomes.
To synthesize available clinical evidence for guiding practice and future research.

Main Methods:

Literature analysis of PubMed/MEDLINE and ClinicalTrials.gov.
Searched for studies on CytoSorb® use in septic shock patients.
Identified inclusion/exclusion criteria, treatment timing, dosing, and outcomes.

Main Results:

Five key recommendations for improved outcomes were identified.
Recommendations include early treatment initiation (12-24h), patient selection (high severity, elevated biomarkers), exclusion criteria (high lactate, low platelets), intense hemoperfusion (>6 L/kg), and frequent adsorbent exchange (q12h).
Further suggestions include therapeutic drug monitoring and adjusted antibiotic protocols, though direct outcome links are pending.

Conclusions:

Current clinical data suggest early, intense CytoSorb® treatment in selected septic shock patients improves survival chances.
Recommendations are based on the best available evidence but require confirmation in future clinical trials.
The findings can inform current clinical practice and guide future research in sepsis management with CytoSorb®.