Organic Sonodynamic Materials for Combination Cancer Immunotherapy

Area of Science:

• Biomedical Engineering
• Oncology
• Immunology

Background:

• Sonodynamic therapy (SDT) offers non-invasive treatment for deep tumors using ultrasound (US).
• Limitations of SDT include low activity and side effects, hindering clinical use.
• Cancer immunotherapy leverages the immune system to fight cancer, presenting synergistic potential with SDT.

Purpose of the Study:

• To review the convergence of SDT and cancer immunotherapy for enhanced cancer treatment.
• To focus on organic materials with high sonodynamic and immunotherapeutic efficiency.
• To discuss the combination of immuno-oncology drugs with organic sonosensitizers.

Main Methods:

• Reviewing literature on SDT and cancer immunotherapy combinations.
• Analyzing organic materials for sonodynamic activity and immunotherapeutic effects.
• Categorizing combinations of immuno-oncology drugs with organic sonosensitizers.

Main Results:

• Organic materials can induce immunogenic cell death via SDT, boosting tumor immunogenicity.
• These materials activate antitumor immunity through immuno-oncology drug pathways.
• Combinations aim to improve treatment efficiency and safety.

Conclusions:

• Combining SDT with cancer immunotherapy, particularly using advanced organic materials, offers a promising strategy.
• This approach can overcome limitations of individual therapies for effective cancer treatment.
• Further research is needed to address challenges for clinical translation.