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Relationship between daytime napping and cardiovascular disease: A two-sample mendelian randomization study.

Shi Chen1, Zhenliang Hu1, Linkang He1

  • 1National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, NO.167, Beilishi Road, Xicheng District, Beijing, 100037, China.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|June 1, 2023
PubMed
Summary

Daytime napping may causally increase the risk of cardiovascular diseases (CVDs). This study found links between genetically predicted napping and heart failure, hypertension, atrial fibrillation, cardiac arrhythmias, and coronary atherosclerosis.

Keywords:
Cardiovascular diseasesCausal relationshipDaytime nappingMendelian randomization

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Area of Science:

  • Cardiovascular epidemiology
  • Genetic epidemiology
  • Public health

Background:

  • Observational studies suggest a link between daytime napping and cardiovascular disease (CVD) risk.
  • Causal evidence for this association remains unclear.

Purpose of the Study:

  • To investigate the relationship between daytime napping and CVDs.
  • To validate the causality of this relationship using Mendelian randomization (MR).

Main Methods:

  • A two-sample Mendelian randomization (MR) approach was employed.
  • Genome-wide association study (GWAS) data for daytime napping (exposure) from UK Biobank.
  • GWAS data for 14 CVDs (outcomes) from the FinnGen consortium.
  • 49 single-nucleotide polymorphisms (SNPs) served as instrumental variables.

Main Results:

  • Genetically predicted daytime napping was associated with an increased risk of five CVDs.
  • Specifically, associations were found for heart failure (OR: 1.71), hypertension (OR: 1.51), atrial fibrillation (OR: 1.71), cardiac arrhythmias (OR: 1.47), and coronary atherosclerosis (OR: 1.77).
  • No significant associations were observed for other CVDs.

Conclusions:

  • Daytime napping is causally associated with an increased risk of several cardiovascular diseases.
  • Findings suggest a potential public health implication for daytime napping habits and cardiovascular health.