Related Experiment Video

Updated: Jul 28, 2025

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

6.4K

Targeting microbiome, drug metabolism, and drug delivery in oncology

Ai Sumiyoshi1, Hiroyuki Fujii2, Yusuke Okuma3

  • 1Department of Pharmacy, National Cancer Center Hospital 5-1-1 Tsukiji Chuo, Tokyo 104-0045, Japan.

Advanced Drug Delivery Reviews
|June 1, 2023
PubMed

Insights

The gut microbiota (GM) influences cancer treatment effectiveness by modulating anti-tumor immunity. Research is exploring GM delivery methods and clinical trials to enhance cancer immunotherapy and patient outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Microbiome Research

Background:

  • Emerging evidence links gut microbiota (GM) to immunomodulation.
  • The microbiome plays a key role in cancer research and pharmacotherapy effectiveness.
  • GM influences anti-tumor immunity and cancer treatment outcomes.

Purpose of the Study:

  • To highlight the importance of studying gut microbiota in cancer.
  • To explore challenges and perspectives for clinical implementation of GM modulation.
  • To review GM's role in enhancing anti-tumor immunity and cancer pharmacotherapy.

Main Methods:

  • Analysis of recent scientific evidence and published reports.
  • Exploration of computer-based analytical methods for big data analysis of GM.
  • Review of challenges in GM delivery methods (oral, endoscopic, intravenous).

Main Results:

  • GM significantly impacts cancer pharmacotherapy outcomes.
  • GM modulation holds potential for enhancing anti-tumor immunity.
  • Targeting GM is being investigated in clinical trials for improved cancer patient outcomes.

Conclusions:

  • Gut microbiota is a critical factor in cancer immunology and treatment.
  • Further research and advanced analytical methods are needed to understand GM's role.
  • Clinical trials are evaluating GM-based strategies to improve cancer immunotherapy and patient prognosis.
Keywords:
CancerConsortiaDrug deliveryFecal microbiota transplantationGut microbiomeImmunotherapyPrebiotics

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.0K

Related Concept Videos

Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
194
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
74
Drug Biotransformation: Overview01:28

Drug Biotransformation: Overview

Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
676
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
6.5K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
596
Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in...
299